The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress

The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress

Objective: Trimetazidine is a piperazine-derived metabolic agent. It exerts cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. In addition, studies confirm that the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway serves a beneficent role in attenuating...

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Bibliographic Details
Main Authors: Wenqing Zheng, Chao Liu
Format: Article
Language:English
Published: KARE Publishing 2019-08-01
Series:Anatolian Journal of Cardiology
Subjects:
trimetazidine
myocardial ischemia/reperfusion injury
cystathionine &#947
-lyase/hydrogen sulfide pathway
apoptosis
oxidative stress.
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-83648

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https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-83648

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