Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

In this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development. Using the adverse outcome pathway (AOP) framework, we analyzed established databases (such as AOP-Wiki) and employ...

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Bibliographic Details
Main Authors: Yong Joo Park, Ha Ryong Kim, Jun Woo Kim, Jong-Hyun Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Kyu Hyuck Chung
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PHMG-p
Lung cancer
Adverse outcome pathway
Non-genotoxic
Carcinogenicity assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324012983

Internet

http://www.sciencedirect.com/science/article/pii/S0147651324012983

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