Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells

Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells

Background: Doxorubicin resistance remains a major therapeutic challenge leading to poor survival prognosis and treatment failure in breast cancer. Although doxorubicin induces massive changes in the transcriptional landscape are well known, potential diagnostic or therapeutic targets associated wit...

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Bibliographic Details
Main Authors: Xuelong Wang, Jizhou Yan, Zhao Ye, Zhiqiang Zhang, Sheng Wang, Shuang Hao, Baiyong Shen, Gang Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
3D genome reorganization
doxorubicin resistance
breast cancer
compartment switching
TAD boundary
enhancer-promoter interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.974750/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.974750/full

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