Different coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice

Different coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice

Abstract Background The surface coating of iron oxide magnetic nanoparticle (MNPs) drives their intracellular trafficking and degradation in endolysosomes, as well as dictating other cellular outcomes. As such, we assessed whether MNP coatings might influence their biodistribution, their accumulatio...

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Bibliographic Details
Main Authors: Yadileiny Portilla, Yilian Fernández-Afonso, Sonia Pérez-Yagüe, Vladimir Mulens-Arias, M. Puerto Morales, Lucía Gutiérrez, Domingo F. Barber
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Nanobiotechnology
Subjects:
Iron oxide nanoparticle
Surface coating
Biodegradation
Biodistribution
Biotransformation
Online Access:https://doi.org/10.1186/s12951-022-01747-5

Internet

https://doi.org/10.1186/s12951-022-01747-5

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