An iRGD‐conjugated photothermal therapy‐responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma

An iRGD‐conjugated photothermal therapy‐responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma

Abstract Although immunotherapy has improved the clinical treatment of lung adenocarcinoma (LUAD), many tumors have poor responses to immunotherapy. In this study, we confirmed that high expression of Cyclin‐Dependent Kinase 7 (CDK7) promoted an immunosuppressive macrophage phenotype and macrophage...

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Bibliographic Details
Main Authors: Rui Cai, Meng Wang, Meiyuan Liu, Xiongjie Zhu, Longbao Feng, Zhongjian Yu, Xia Yang, Zhiwu Zhang, Huili Guo, Rui Guo, Yanfang Zheng
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Bioengineering & Translational Medicine
Subjects:
CDK7
gold nanoparticles
lung adenocarcinoma
M2 macrophages
necroptosis
Online Access:https://doi.org/10.1002/btm2.10430

Internet

https://doi.org/10.1002/btm2.10430

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