Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC

Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC

Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20–30% of patients demonstrate primary resistance to EGFR-TKIs, which leads to the failure of EGFR-TKI treatment. The mech...

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Bibliographic Details
Main Authors: Dantong Sun, Yan Zhu, Jingjuan Zhu, Junyan Tao, Xiaojuan Wei, Yang Wo, Helei Hou
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Medicine
Subjects:
MDM2 amplification
Primary resistance
EGFR-TKIs
NSCLC
Prognosis
Online Access:http://link.springer.com/article/10.1186/s10020-020-00193-z

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http://link.springer.com/article/10.1186/s10020-020-00193-z

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