Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

Novel semisynthetic coumarin derivatives were synthesized to be developed as chemotherapeutic anticancer agents through topoisomerase II, VEGFR2 inhibition that leads to apoptotic cancer cell death. The coumarin amino acids and dipeptides derivatives were prepared by the reaction of coumarin-3-carbo...

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Bibliographic Details
Main Authors: Mohamed S. Gomaa, Ibrahim A. I. Ali, Gaber El Enany, El Sayed H. El Ashry, Samir M. El Rayes, Walid Fathalla, Abdulghany H. A. Ahmed, Samar A. Abubshait, Haya A. Abubshait, Mohamed S. Nafie
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
amino acids
coumarin
DCC coupling
dipeptides
VEGFR2
topoisomerase II
Online Access:https://www.mdpi.com/1420-3049/27/23/8279

Internet

https://www.mdpi.com/1420-3049/27/23/8279

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