USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

Abstract A hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, is amplified and activated in BLCA. However, direct targeting of the c-Myc oncoprot...

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Bibliographic Details
Main Authors: Mingxing Li, Jingtian Yu, Lingao Ju, Yejinpeng Wang, Wan Jin, Renjie Zhang, Wan Xiang, Meng Ji, Wenzhi Du, Gang Wang, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06446-7

Internet

https://doi.org/10.1038/s41419-024-06446-7

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