Tumor organoids: applications in cancer modeling and potentials in precision medicine
Abstract Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure and an unfavorable prognosis. Personalized tumor models faithfully capturing the t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-022-01278-4 |
| _version_ | 1828796283493548032 |
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| author | Hanxiao Xu Dechao Jiao Aiguo Liu Kongming Wu |
| author_facet | Hanxiao Xu Dechao Jiao Aiguo Liu Kongming Wu |
| author_sort | Hanxiao Xu |
| collection | DOAJ |
| description | Abstract Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure and an unfavorable prognosis. Personalized tumor models faithfully capturing the tumor heterogeneity of individual patients are urgently needed for precision medicine. Advances in stem cell culture have given rise to powerful organoid technology for the generation of in vitro three-dimensional tissues that have been shown to more accurately recapitulate the structures, specific functions, molecular characteristics, genomic alterations, expression profiles, and tumor microenvironment of primary tumors. Tumoroids in vitro serve as an important component of the pipeline for the discovery of potential therapeutic targets and the identification of novel compounds. In this review, we will summarize recent advances in tumoroid cultures as an excellent tool for accurate cancer modeling. Additionally, vascularization and immune microenvironment modeling based on organoid technology will also be described. Furthermore, we will summarize the great potential of tumor organoids in predicting the therapeutic response, investigating resistance-related mechanisms, optimizing treatment strategies, and exploring potential therapies. In addition, the bottlenecks and challenges of current tumoroids will also be discussed in this review. |
| first_indexed | 2024-12-12T04:19:53Z |
| format | Article |
| id | doaj.art-4bb2e2e32904404a9260a5ed214b2499 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-12T04:19:53Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-4bb2e2e32904404a9260a5ed214b24992022-12-22T00:38:20ZengBMCJournal of Hematology & Oncology1756-87222022-05-0115112010.1186/s13045-022-01278-4Tumor organoids: applications in cancer modeling and potentials in precision medicineHanxiao Xu0Dechao Jiao1Aiguo Liu2Kongming Wu3Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou UniversityAbstract Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure and an unfavorable prognosis. Personalized tumor models faithfully capturing the tumor heterogeneity of individual patients are urgently needed for precision medicine. Advances in stem cell culture have given rise to powerful organoid technology for the generation of in vitro three-dimensional tissues that have been shown to more accurately recapitulate the structures, specific functions, molecular characteristics, genomic alterations, expression profiles, and tumor microenvironment of primary tumors. Tumoroids in vitro serve as an important component of the pipeline for the discovery of potential therapeutic targets and the identification of novel compounds. In this review, we will summarize recent advances in tumoroid cultures as an excellent tool for accurate cancer modeling. Additionally, vascularization and immune microenvironment modeling based on organoid technology will also be described. Furthermore, we will summarize the great potential of tumor organoids in predicting the therapeutic response, investigating resistance-related mechanisms, optimizing treatment strategies, and exploring potential therapies. In addition, the bottlenecks and challenges of current tumoroids will also be discussed in this review.https://doi.org/10.1186/s13045-022-01278-4OrganoidPatient-derived xenograftsCancerTumor microenvironmentTherapy response predictionDrug discovery |
| spellingShingle | Hanxiao Xu Dechao Jiao Aiguo Liu Kongming Wu Tumor organoids: applications in cancer modeling and potentials in precision medicine Journal of Hematology & Oncology Organoid Patient-derived xenografts Cancer Tumor microenvironment Therapy response prediction Drug discovery |
| title | Tumor organoids: applications in cancer modeling and potentials in precision medicine |
| title_full | Tumor organoids: applications in cancer modeling and potentials in precision medicine |
| title_fullStr | Tumor organoids: applications in cancer modeling and potentials in precision medicine |
| title_full_unstemmed | Tumor organoids: applications in cancer modeling and potentials in precision medicine |
| title_short | Tumor organoids: applications in cancer modeling and potentials in precision medicine |
| title_sort | tumor organoids applications in cancer modeling and potentials in precision medicine |
| topic | Organoid Patient-derived xenografts Cancer Tumor microenvironment Therapy response prediction Drug discovery |
| url | https://doi.org/10.1186/s13045-022-01278-4 |
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