A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

Neutrophil responses against pathogens must be balanced between protection and immunopathology. Factors that determine these outcomes are not well-understood. In a mouse model of genital herpes simplex virus-2 (HSV-2) infection, which results in severe genital inflammation, antibody-mediated neutrop...

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Bibliographic Details
Main Authors: Tania Lebratti, Ying Shiang Lim, Adjoa Cofie, Prabhakar Andhey, Xiaoping Jiang, Jason Scott, Maria Rita Fabbrizi, Ayşe Naz Ozantürk, Christine Pham, Regina Clemens, Maxim Artyomov, Mary Dinauer, Haina Shin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
neutrophils
interferon
genital herpes
immunopathology
Online Access:https://elifesciences.org/articles/65762

Internet

https://elifesciences.org/articles/65762

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