The hypothalamic–pituitary–thyroid axis is intact in male Irs4 knockout mice

The hypothalamic–pituitary–thyroid axis is intact in male Irs4 knockout mice

Objective: Loss of function mutations in the insulin receptor substrate 4 (IRS4) gene cause a rare form of X-linked congenital central hypothyroidism in boys and men. Affected individuals show decreased thyroid-stimulating hormone (TSH) secretion. Members of the IRS family canonically act as scaffol...

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Bibliographic Details
Main Authors: Emilie Brûlé, Xiang Zhou, Ying Wang, Evan R S Buddle, Luisina Ongaro, Mary Loka, Anita Boelen, Daniel J Bernard
Format: Article
Language:English
Published: Bioscientifica 2024-02-01
Series:European Thyroid Journal
Subjects:
hormone
hypothyroidism
mutation
pituitary
thyroid
Online Access:https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0054.xml

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https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0054.xml

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