3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

Abstract Background Immune checkpoint inhibitors that target programmed cell death protein 1 (PD-1) have obtained encouraging results, but a fraction of tumor patients failed to respond to anti-PD-1 treatment due to the existence of multiple immune suppressive elements such as myeloid-derived suppre...

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Bibliographic Details
Main Authors: Qi Sun, Lin Xiao, Zhiying Cui, Yaping Yang, Junting Ma, Zhen Huang, Junfeng Zhang, Jiangning Chen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Chinese Medicine
Subjects:
3,3′-Diindolylmethane
Cancer immunotherapy
Adjunctive therapy
PD-1 blockade
Myeloid-derived suppressor cells
Online Access:https://doi.org/10.1186/s13020-022-00638-z

Internet

https://doi.org/10.1186/s13020-022-00638-z

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