Sustained Systemic Levels of IL-6 Impinge Early Muscle Growth and Induce Muscle Atrophy and Wasting in Adulthood

Sustained Systemic Levels of IL-6 Impinge Early Muscle Growth and Induce Muscle Atrophy and Wasting in Adulthood

IL-6 is a pleiotropic cytokine that can exert different and opposite effects. The muscle-induced and transient expression of IL-6 can act in an autocrine or paracrine manner, stimulating anabolic pathways associated with muscle growth, myogenesis, and with regulation of energy metabolism. In contras...

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Bibliographic Details
Main Authors: Laura Pelosi, Maria Grazia Berardinelli, Laura Forcina, Francesca Ascenzi, Emanuele Rizzuto, Marco Sandri, Fabrizio De Benedetti, Bianca Maria Scicchitano, Antonio Musarò
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
interleukin-6
skeletal muscle
muscle growth
muscle atrophy
PGC-1α
Online Access:https://www.mdpi.com/2073-4409/10/7/1816

Internet

https://www.mdpi.com/2073-4409/10/7/1816

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