Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease

Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease

Abstract Patients with sickle cell disease (SCD) have a high prevalence of RBC alloimmunization. However, underlying mechanisms are poorly understood. Given that proinflammatory type 1 interferons (IFNα/β) and interferon stimulated genes (ISGs) promote alloimmunization in mice, we hypothesized that...

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Bibliographic Details
Main Authors: Emaan Madany, June Lee, Chelsea Halprin, Jina Seo, Nicole Baca, Fataneh Majlessipour, Jeanne E. Hendrickson, Samuel H. Pepkowitz, Chelsea Hayes, Ellen Klapper, David R. Gibb
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:eJHaem
Subjects:
type 1 interferons
alloimmunization
sickle cell disease
Online Access:https://doi.org/10.1002/jha2.270

Internet

https://doi.org/10.1002/jha2.270

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