SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure

SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure

Alcohol abuse, reported by 1/8th critically ill patients, is an independent risk factor for death in sepsis. Sepsis kills over 270,000 patients/year in the US. We reported that the ethanol-exposure suppresses innate-immune response, pathogen clearance, and decreases survival in sepsis-mice via sirt...

Full description

Bibliographic Details
Main Authors: Anugraha Gandhirajan, Sanjoy Roychowdhury, Christopher Kibler, Emily Cross, Susamma Abraham, Annett Bellar, Laura E. Nagy, Rachel Greenberg Scheraga, Vidula Vachharajani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
ethanol-exposure
phagocytosis
LC3-associated phagocytosis
sepsis
macrophage
Sirtuin 2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1079962/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1079962/full

Similar Items