Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment

Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment

Raloxifene hydrochloride (RLX), an antiosteoporotic agent, has been utilized for guarding against breast cancer and recently, for the disease management owing to its estrogen antagonist activity. Nevertheless, RLX exhibits poor bioavailability that could be attributed to reduced water solubility and...

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Bibliographic Details
Main Authors: Hibah M. Aldawsari, Osama A. A. Ahmed, Nabil A. Alhakamy, Thikryat Neamatallah, Usama A. Fahmy, Shaimaa M. Badr-Eldin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
raloxifene hydrochloride
emulsomes
factorial design
cell cycle analysis
apoptosis
mitochondrial membrane potential
Online Access:https://www.mdpi.com/1999-4923/13/6/783

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https://www.mdpi.com/1999-4923/13/6/783

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