Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer

Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer

Abstract Members of the human epidermal growth factor receptor (HER) family play a significant role in bladder cancer progression and may underlie the development of chemotherapy resistance. Dacomitinib is an irreversible tyrosine kinase inhibitor with structural specificity for the catalytic domain...

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Detalles Bibliográficos
Autores principales: Petros D. Grivas, Kathleen C. Day, Andreas Karatsinides, Alyssa Paul, Nazia Shakir, Iya Owainati, Monica Liebert, Lakshmi P. Kunju, Dafydd Thomas, Maha Hussain, Mark L. Day
Formato: Artículo
Lenguaje:English
Publicado: BMC 2013-10-01
Colección:Molecular Medicine
Materias:
Dacomitinib
Bladder Cancer Xenografts
Non-obese Diabetic/severe Combined Immunodeficiency (NOD/SCID)
Epidermal Growth Factor Receptor (EGFR)
Lapatinib
Acceso en línea:https://doi.org/10.2119/molmed.2013.00108

Internet

https://doi.org/10.2119/molmed.2013.00108

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