Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

Abstract Background Osteosarcoma patients often experience poor outcomes despite chemotherapy treatment, likely due in part to various mechanisms of tumor cell innate and/or acquired drug resistance. Exosomes, microvesicles secreted by cells, have been shown to play a role in drug resistance, but a...

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Bibliographic Details
Main Authors: Marcus A. Weinman, Stephen A. Ramsey, Haley J. Leeper, Jacqueline V. Brady, Andrew Schlueter, Stanislau Stanisheuski, Claudia S. Maier, Tasha Miller, Carl E. Ruby, Shay Bracha
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
Exosomes
Carboplatin
Drug resistance
Canine
Online Access:https://doi.org/10.1186/s12935-021-01943-7

Internet

https://doi.org/10.1186/s12935-021-01943-7

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