Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors.

Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors.

BCR-ABL tyrosine kinase inhibitors (TKIs) have dramatically improved survival in Philadelphia chromosome-positive leukemias. Newer BCR-ABL TKIs provide superior cancer outcomes but with increased risk of acute arterial thrombosis, which further increases in patients with cardiovascular comorbidities...

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Bibliographic Details
Main Authors: Yihua Wang, Richard J Travers, Alanna Farrell, Qing Lu, Jennifer L Bays, Alec Stepanian, Christopher Chen, Iris Z Jaffe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294438&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294438&type=printable

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