Hepatitis B Core Antigen Impairs the Polarization While Promoting the Production of Inflammatory Cytokines of M2 Macrophages via the TLR2 Pathway

Hepatitis B Core Antigen Impairs the Polarization While Promoting the Production of Inflammatory Cytokines of M2 Macrophages via the TLR2 Pathway

Although several evidences suggesting the vital roles that innate immunity plays in the persistence and elimination of chronic hepatitis B virus (CHB) infection, the exact mechanism is still complicated. Here, we successfully polarized monocytes derived from healthy human peripheral blood mononuclea...

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Bibliographic Details
Main Authors: Hongyu Yi, Ye Zhang, Xiaofei Yang, Mengyuan Li, Haifeng Hu, Jie Xiong, Ning Wang, Jingyi Jin, Yusi Zhang, Yun Song, Xian Wang, Lihua Chen, Jianqi Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
hepatitis B virus
HBV core protein
macrophage polarization
Toll-like receptor 2
inflammatory cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00535/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00535/full

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