The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance

The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance

IntroductionThe dlt operon encodes proteins responsible for the esterification of positively charged D-alanine on the wall teichoic acids and lipoteichoic acids of Gram-positive bacteria. This structural modification of the bacterial anionic surface in several species has been described to alter the...

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Bibliographic Details
Main Authors: Pierre-Alexandre Lacotte, Sandrine Denis-Quanquin, Eva Chatonnat, Julie Le Bris, David Leparfait, Thierry Lequeux, Isabelle Martin-Verstraete, Thomas Candela
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
cell wall
polysaccharides
lipoteichoic acid
D-alanylation
CAMPs
antibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1267662/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1267662/full

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