Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA

Viral genomic RNA is packaged into virions with high specificity and selectivity. However, in vitro the Gag specificity towards viral RNA is obscured when measured in buffers containing physiological salt. Interestingly, when the binding is challenged by increased salt concentration, the addition of...

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Bibliographic Details
Main Authors: Tomas Kroupa, Siddhartha A. K. Datta, Alan Rein
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/4/394