Transduction of inflammation from peripheral immune cells to the hippocampus induces neuronal hyperexcitability mediated by Caspase-1 activation

Transduction of inflammation from peripheral immune cells to the hippocampus induces neuronal hyperexcitability mediated by Caspase-1 activation

Background: Recent studies report infiltration of peripheral blood mononuclear cells (PBMCs) into the central nervous system (CNS) in epileptic disorders, suggestive of a potential contribution of PBMC extravasation to the generation of seizures. Nevertheless, the underlying mechanisms involved in P...

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Bibliographic Details
Main Authors: Tarek Shaker, Bidisha Chattopadhyaya, Bénédicte Amilhon, Graziella Di Cristo, Alexander G. Weil
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Neurobiology of Disease
Subjects:
Caspase-1
hippocampus
Hyperexcitability
Inflammasome
Organotypic cultures
Peripheral blood mononuclear cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002849

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http://www.sciencedirect.com/science/article/pii/S0969996121002849

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