Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis

Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis

Pentavalent antimonials have saved the lives of thousands of Leishmania-infected patients more than seventy years but, unfortunately, they are highly toxic and require parenteral delivery. Therefore, the search for safer and orally delivered alternative is a need. This paper describes the antileishm...

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Bibliographic Details
Main Authors: Mariela Ferreira de Vasconcelos, Edézio Ferreira da Cunha-Júnior, Valter Viana de Andrade-Neto, Larissa Moreira Siqueira, Cláudia Masini d’Avila-Levy, Marcele Moreth, Wilson Cunico, Marcus Vinícius Nora de Souza, Cláudia Regina Brandão Gomes, Eduardo Caio Torres-Santos
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Leishmaniasis chemotherapy
Hydroxyethylamines
Oral bioavailability
In silico ADMET
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320714000359

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http://www.sciencedirect.com/science/article/pii/S2211320714000359

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