Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats

Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats

The aim of this work was to study the healing activity of amitriptyline (Amitrip) in rat diabetic wounds. A nanoformula of the drug was prepared as Amitrip-based biodegradable PEG-PLGA self-assembled nanoparticles (Amitrip-NPs) with a mean particle size of 67.4 nm. An in vivo investigation was condu...

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Bibliographic Details
Main Authors: Hani Z. Asfour, Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Mohamed A. El-moselhy, Waleed Y. Rizg, Adel F. Alghaith, Basma G. Eid, Ashraf B. Abdel-Naim
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
diabetic wounds
amitriptyline
polymers
PEG-PLGA
nanoparticles
Online Access:https://www.mdpi.com/1999-4923/14/9/1792

Internet

https://www.mdpi.com/1999-4923/14/9/1792

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