Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments

Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments

Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. Aidi injection (ADI) is a representative antitumor medication based on Chinese herbal injection, but its antitumor mechanisms are still poorly understood. Materials and methods In this work, the subcutaneous xenograft...

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Bibliographic Details
Main Authors: Haojia Wang, Zhishan Wu, Xiaotian Fan, Chao Wu, Shan Lu, Libo Geng, Antony Stalin, Yingli Zhu, Fanqin Zhang, Jiaqi Huang, Pengyun Liu, Huiying Li, Leiming You, Jiarui Wu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Chinese Medicine
Subjects:
Pancreatic cancer
Aidi injection
Network pharmacology
Molecular docking
Pharmacodynamic evaluation
Online Access:https://doi.org/10.1186/s13020-023-00710-2

Internet

https://doi.org/10.1186/s13020-023-00710-2

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