Heterologous Combination of ChAdOx1 and MVA Vectors Expressing Protein NS1 as Vaccination Strategy to Induce Durable and Cross-Protective CD8+ T Cell Immunity to Bluetongue Virus

Heterologous Combination of ChAdOx1 and MVA Vectors Expressing Protein NS1 as Vaccination Strategy to Induce Durable and Cross-Protective CD8+ T Cell Immunity to Bluetongue Virus

The sequence of non-structural protein NS1 of bluetongue virus (BTV), which contains immunodominant CD8+ T cell epitopes, is highly conserved among BTV serotypes, and has therefore become a major tool in the development of a universal BTV vaccine. In this work, we have engineered multiserotype BTV v...

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Bibliographic Details
Main Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Ruymán Alonso-Ravelo, Eva Calvo-Pinilla, Alejandro Marín-López, Sandra Moreno, Gema Lorenzo, Julio Benavides, Sarah Gilbert, Aitor Nogales, Javier Ortego
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Vaccines
Subjects:
bluetongue virus (BTV)
modified vaccinia Ankara (MVA)
Chimpanzee adenovirus (ChAdOx1), vaccine
cellular response
protein NS1
Online Access:https://www.mdpi.com/2076-393X/8/3/346

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https://www.mdpi.com/2076-393X/8/3/346

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