Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury

Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury

Abstract Background Spinal cord injury (SCI) is a severe traumatic disease which causes high disability and mortality rates. The molecular pathological features after spinal cord injury mainly involve the inflammatory response, microglial and neuronal apoptosis, abnormal proliferation of astrocytes,...

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Bibliographic Details
Main Authors: Yuluo Rong, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Pengyu Tang, Dongdong Jiang, Jin Fan, Guoyong Yin, Wei Liu, Weihua Cai
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Astrocyte
Small extracellular vesicles
CCL2
Microglia
Neuron
Online Access:https://doi.org/10.1186/s12974-021-02268-y

Internet

https://doi.org/10.1186/s12974-021-02268-y

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