Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Abstract Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous sma...

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Bibliographic Details
Main Authors: Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46922-4

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https://doi.org/10.1038/s41467-024-46922-4

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