Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

Summary: Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autophagy; however, it is unknown whether p62 can exist...

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Bibliographic Details
Main Authors: Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O’Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002638

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http://www.sciencedirect.com/science/article/pii/S2211124724002638

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