Synthesis and Structure-Activity Relationships of Novel Ecdysteroid Dioxolanes as MDR Modulators in Cancer

Synthesis and Structure-Activity Relationships of Novel Ecdysteroid Dioxolanes as MDR Modulators in Cancer

Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell lin...

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Bibliographic Details
Main Authors: Ana Martins, József Csábi, Attila Balázs, Diána Kitka, Leonard Amaral, József Molnár, András Simon, Gábor Tóth, Attila Hunyadi
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
ecdysteroids
20-hydroxyecdysone
acetonide
dioxolane
stereochemistry
cancer
multi-drug resistance
P-glycoprotein
ABCB1 transporter
efflux pump
Online Access:http://www.mdpi.com/1420-3049/18/12/15255

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http://www.mdpi.com/1420-3049/18/12/15255

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