Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

ABSTRACT Viral 2′,5′-phosphodiesterases (2′,5′-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2′,5′-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) to localize and...

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Bibliographic Details
Main Authors: Elona Gusho, Rong Zhang, Babal K. Jha, Joshua M. Thornbrough, Beihua Dong, Christina Gaughan, Ruth Elliott, Susan R. Weiss, Robert H. Silverman
Format: Article
Language:English
Published: American Society for Microbiology 2014-08-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01312-14

Internet

https://journals.asm.org/doi/10.1128/mBio.01312-14

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