Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

Chemically modified forms of tetraiodothyroacetic acid (tetrac), an L-thyroxine derivative, have been shown to exert their anticancer activity at plasma membrane integrin αvβ3 of tumor cells. Via a specific hormone receptor on the integrin, tetrac-based therapeutic agents modulate expression of gene...

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Bibliographic Details
Main Authors: Gennadi V. Glinsky, Kavitha Godugu, Thangirala Sudha, Mehdi Rajabi, Sridar V. Chittur, Aleck A. Hercbergs, Shaker A. Mousa, Paul J. Davis
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Metabolites
Subjects:
ATP synthase
cancer cells
mitochondria
glioblastoma
integrin αvβ3
NADH dehydrogenase
Online Access:https://www.mdpi.com/2218-1989/12/4/325

Internet

https://www.mdpi.com/2218-1989/12/4/325

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