Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation

Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation

Abstract Background We have reported the positive association of the cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schistosoma japonicum (Sj) infection, and TLR4 signaling controlled this axis. However, how COX-2 regulates immune response during Sj infection is...

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Bibliographic Details
Main Authors: Zhang Qi, Chen Lan, Ji Xiaofang, Tang Juanjuan, Fu Cheng, Huang Ting, Shen Erxia, Li Zi
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Parasites & Vectors
Subjects:
COX-2
NS398
Granulomatous inflammation
Cellular immunoregulation
Schistosoma japonicum
Online Access:https://doi.org/10.1186/s13071-022-05201-1

Internet

https://doi.org/10.1186/s13071-022-05201-1

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