IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation

IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation

Abstract Retinal degeneration is a kind of neurodegeneration characterized by progressive neuronal death and dysfunction of retinal pigment epithelium (RPE) cells, leading to permanent visual impairment. It still lacks effective therapeutic options and new drugs are highly warranted. In this study,...

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Bibliographic Details
Main Authors: Tian Zhou, Ziqi Yang, Biyan Ni, Hong Zhou, Huiyi Xu, Xiaojing Lin, Yingmin Li, Chunqiao Liu, Rong Ju, Jian Ge, Chang He, Xialin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05433-0

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https://doi.org/10.1038/s41419-022-05433-0

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