Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

Alzheimer's disease is a neurodegenerative disorder characterized by a decline in cognitive function. The β-amyloid (Aβ) hypothesis suggests that Aβ peptides can spontaneously aggregate into β-fragment-containing oligomers and protofibrils, and this activation of the amyloid pathway alters Ca2+...

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Bibliographic Details
Main Authors: Lin Lin Song, Yuan Qing Qu, Yong Pei Tang, Xi Chen, Hang Hong Lo, Li Qun Qu, Yun Xiao Yun, Vincent Kam Wai Wong, Rui Long Zhang, Hui Miao Wang, Meng Han Liu, Wei Zhang, Hui Xia Zhang, Joyce Tsz Wai Chan, Cai Ren Wang, Jian Hui Wu, Betty Yuen Kwan Law
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
Alzheimer's disease
Aβ aggregates
Hyperoside
Neurotoxicity
Endoplasmic reticulum-mitochondrial-Ca2+
Ryanodine receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000381

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http://www.sciencedirect.com/science/article/pii/S2213231723000381

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