Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis

Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis

BackgroundAutologous haematopoietic stem cell transplantation (AHSCT) is highly effective in reducing new inflammatory activity in aggressive multiple sclerosis (MS). A remarkable decrease of serum neurofilament light chains (sNfL) concentration, a marker of axonal damage, was reported in MS followi...

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Bibliographic Details
Main Authors: Alice Mariottini, Leonardo Marchi, Chiara Innocenti, Maria Di Cristinzi, Matteo Pasca, Stefano Filippini, Alessandro Barilaro, Claudia Mechi, Arianna Fani, Benedetta Mazzanti, Tiziana Biagioli, Francesca Materozzi, Riccardo Saccardi, Luca Massacesi, Anna Maria Repice
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neurology
Subjects:
hematopoietic (stem) cell transplantation (HSCT)
multiple sclerosis
neurofilament light (NfL)
biomarker
brain atrophy
PIRA
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.820256/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.820256/full

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