Multiple Mutations in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> MmpL3 Increase Resistance to MmpL3 Inhibitors

Multiple Mutations in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> MmpL3 Increase Resistance to MmpL3 Inhibitors

ABSTRACT The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. Numerous structurally diverse pharmacophores have been identified as inhibitors of MmpL3 largely based on the...

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Bibliographic Details
Main Authors: Matthew B. McNeil, Theresa O’Malley, Devon Dennison, Catherine D. Shelton, Bjorn Sunde, Tanya Parish
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mSphere
Subjects:
cell wall
mycobacteria
antibiotic resistance
drug discovery
mycolic acids
mechanism of resistance
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00985-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00985-20

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