The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba

Abstract Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host organisms. Diels-Alderases (DAs), functionally unique enzymes catalysing [4 + 2] cycloaddition reactions, have received considerable research inter...

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Bibliographic Details
Main Authors: Qi Ding, Nianxin Guo, Lei Gao, Michelle McKee, Dongshan Wu, Jun Yang, Junping Fan, Jing-Ke Weng, Xiaoguang Lei
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46845-0