Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells

Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells

Zhi-zi-chi Decoction (ZZCD), composed of Fructus Gardeniae (Zhizi in Chinese, ZZ in brief) and Semen sojae praeparatum (Dandouchi in Chinese, DDC in brief), has been used as a drug therapy for depression for thousands of years in China. However, the antidepressant mechanism of ZZCD still remains unk...

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Bibliographic Details
Main Authors: Yin Zhang, Yusha Luo, Dongqi Zhang, Bo Pang, Jun Wen, Tingting Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
ZZCD
compatibility
antidepressant effect
PC12 cell
chronic unpredictable mild stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.625108/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.625108/full

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