Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair

Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair

Rheumatoid arthritis (RA) is a common chronic disease dominated by inflammatory synovitis, which is characterized with hyperplastic synovium, up-regulated matrix metalloproteinase (MMP) expression, hypoxic joint cavity and excessive reactive oxygen species (ROS) accumulation. Such local adverse micr...

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Bibliographic Details
Main Authors: Jun Tao, Peng Yang, Mingying Gao, Fan Zhang, Yongzhong Wu, Yan Jiang, Yunxuan Ning, Zhenglin Li, Fanrong Ai
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Rheumatoid arthritis
Methotrexate
Macrophage polarization
Lipogel
Reactive oxygen species
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423000820

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http://www.sciencedirect.com/science/article/pii/S2590006423000820

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