AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells

AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells

AS1041 is a novel synthesized anthraquinone lactone derivative of marine natural compound aspergiolide A (ASP-A) with new structure skeleton and marked cytotoxicity in cancer cells. To study its cytotoxicity in detail, we evaluated its activity on human K562 chronic myelogenous leukemia cells and in...

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Bibliographic Details
Main Authors: Fengli Yuan, Liang Qiao, Yinghan Chen, Xin Qi, Yankai Liu, Dehai Li, Qianqun Gu, Jing Li, Ming Liu
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Marine Drugs
Subjects:
aspergiolide A derivatives
apoptosis
cytotoxicity
ERK
topoisomerases
Online Access:https://www.mdpi.com/1660-3397/15/11/346

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https://www.mdpi.com/1660-3397/15/11/346

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