ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice

ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice

To study the role of low levels of high density lipoprotein (HDL) and apolipoprotein (apo) A-I in atherosclerosis risk, human apoB transgenic mice (HuBTg) were crossed with apoA-I-deficient (apoA-I–/–) mice. After a high fat challenge, total cholesterol levels increased drastically due to an increas...

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Bibliographic Details
Main Authors: Emanuel Voyiaziakis, Ira J. Goldberg, Andrew S. Plump, Edward M. Rubin, Jan L. Breslow, Li-Shin Huang
Format: Article
Language:English
Published: Elsevier 1998-02-01
Series:Journal of Lipid Research
Subjects:
apoA-I
apoB
atherosclerosis
hypertriglyceridemia
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338931

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http://www.sciencedirect.com/science/article/pii/S0022227520338931

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