Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Experimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors.

Bibliographic Details
Main Authors: Kelly J. Culhane, Tejas M. Gupte, Indrani Madhugiri, Chetan J. Gadgil, Sivaraj Sivaramakrishnan
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28789-5