Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling
Experimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28789-5 |
| _version_ | 1818137676656672768 |
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| author | Kelly J. Culhane Tejas M. Gupte Indrani Madhugiri Chetan J. Gadgil Sivaraj Sivaramakrishnan |
| author_facet | Kelly J. Culhane Tejas M. Gupte Indrani Madhugiri Chetan J. Gadgil Sivaraj Sivaramakrishnan |
| author_sort | Kelly J. Culhane |
| collection | DOAJ |
| description | Experimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors. |
| first_indexed | 2024-12-11T10:00:05Z |
| format | Article |
| id | doaj.art-4c100b14cacb4d8580a81188724aed25 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T10:00:05Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4c100b14cacb4d8580a81188724aed252022-12-22T01:12:09ZengNature PortfolioNature Communications2041-17232022-03-011311910.1038/s41467-022-28789-5Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signalingKelly J. Culhane0Tejas M. Gupte1Indrani Madhugiri2Chetan J. Gadgil3Sivaraj Sivaramakrishnan4Department of Genetics, Cell Biology and Development, University of MinnesotaDepartment of Genetics, Cell Biology and Development, University of MinnesotaChemical Engineering Division, CSIR-National Chemical LaboratoryChemical Engineering Division, CSIR-National Chemical LaboratoryDepartment of Genetics, Cell Biology and Development, University of MinnesotaExperimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors.https://doi.org/10.1038/s41467-022-28789-5 |
| spellingShingle | Kelly J. Culhane Tejas M. Gupte Indrani Madhugiri Chetan J. Gadgil Sivaraj Sivaramakrishnan Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling Nature Communications |
| title | Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling |
| title_full | Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling |
| title_fullStr | Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling |
| title_full_unstemmed | Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling |
| title_short | Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling |
| title_sort | kinetic model of gpcr g protein interactions reveals allokairic modulation of signaling |
| url | https://doi.org/10.1038/s41467-022-28789-5 |
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