Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation

Abstract CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. However, regulatory T cells (Tregs) also rely on CD2...

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Bibliographic Details
Main Authors: Jacobo López-Abente, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Juan Miguel Gil-Jaurena, Maribel Clemente, Simon Urschel, Lori West, Marjorie Pion, Rafael Correa-Rocha
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80567-9

Internet

https://doi.org/10.1038/s41598-020-80567-9

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