Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions

Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare problem with limited therapeutic options. Progress in this field depends on the availability of reliable preclinical models. Human precision-cut liver slices (PCLSs) have been employed to replicate the initiatio...

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Bibliographic Details
Main Authors: Mei Li, Frederik T. Larsen, Marius C. van den Heuvel, Konstanze Gier, Alan R. Gorter, Dorenda Oosterhuis, Johan Bijzet, Vincent E. de Meijer, Kim Ravnskjaer, Anika Nagelkerke, Peter Olinga
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Nutrients
Subjects:
precision-cut liver slices (PCLSs)
long-term incubation
metabolic dysfunction-associated steatotic liver disease (MASLD)
non-alcoholic fatty liver disease (NAFLD)
hepatic steatosis
liver fibrosis
Online Access:https://www.mdpi.com/2072-6643/16/5/626

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https://www.mdpi.com/2072-6643/16/5/626

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