A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity

Abstract Stroke is the second leading cause of death and disability worldwide. Current treatments, such as pharmacological thrombolysis or mechanical thrombectomy, reopen occluded arteries but do not protect against ischemia‐induced damage that occurs before reperfusion or neuronal damage induced by...

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Bibliographic Details
Main Authors: Alexandra Chovsepian, Daniel Berchtold, Katarzyna Winek, Uta Mamrak, Inés Ramírez Álvarez, Yanina Dening, Dominika Golubczyk, Luis Weitbrecht, Claudia Dames, Marine Aillery, Celia Fernandez‐Sanz, Zdzislaw Gajewski, Marianne Dieterich, Miroslaw Janowski, Peter Falkai, Piotr Walczak, Nikolaus Plesnila, Andreas Meisel, Francisco Pan‐Montojo
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Advanced Science
Subjects:
glutamate‐dependent excitotoxicity
ischemia–reperfusion damage
neuroprotection
Stroke
Online Access:https://doi.org/10.1002/advs.202103265

Internet

https://doi.org/10.1002/advs.202103265

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