scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

Abstract CRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand the effect of genetic perturbations including single nucleotide variants (SNVs) associated with diseases. Interpretation of these data is currently limited as genotypes cannot be accurately inferred fr...

Full description

Bibliographic Details
Main Authors: Sarah E. Cooper, Matthew A. Coelho, Magdalena E. Strauss, Aleksander M. Gontarczyk, Qianxin Wu, Mathew J. Garnett, John C. Marioni, Andrew R. Bassett
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Subjects:
Single-cell CRISPR screen
SNV
GWAS
Base editor
Causal variant
VUS
Online Access:https://doi.org/10.1186/s13059-024-03169-y

Internet

https://doi.org/10.1186/s13059-024-03169-y

Similar Items