Development of a HPLC Method for Analysis of a Combination of Clofazimine, Isoniazid, Pyrazinamide, and Rifampicin Incorporated into a Dermal Self-Double-Emulsifying Drug Delivery System

We describe the development and validation of a new high performance liquid chromatography (HPLC) method for analysis of a combination of the first-line anti-tubercular drugs isoniazid, pyrazinamide, and rifampicin together with clofazimine. This is a unique challenge since clofazimine and rifampici...

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Bibliographic Details
Main Authors: Daniélle van Staden, Richard K. Haynes, Frank Van der Kooy, Joe M. Viljoen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Methods and Protocols
Subjects:
Online Access:https://www.mdpi.com/2409-9279/6/6/104